Sean Duffy was born in San Diego in 1966 and currently lives and works in Valencia, California. Duffy earned his B.A. from the University of California, San Diego, in 1988 and his M.F.A. from the University of California, Irvine, in 1992.

Duffy's solo exhibitions include Sean Duffy, Laguna Art Museum (2010); Can't Stop It, Susanne Vielmetter Los Angeles Projects (2009); Hilites, Miami Art Museum (2008); The Grove, Luckman Gallery, California State University, Los Angeles (2007); Group Show Part 2, Susanne Vielmetter Berlin Projects (2007); Temporary Worker, Susanne Vielmetter Los Angeles Projects (2004); Sorry Entertainer, Howard House, Seattle (2003); and Endless Sunday, Miramar Artist Project Space, Santa Barbara Contemporary Arts Forum (2000).

Group exhibitions include Because I Say So..., Patricia & Phillip Frost Art Museum, Miami (2009); Don't Let Me Be Misunderstood, World Class Boxing, Debra and Dennis Scholl Collection, Miami (2008); Like Lifelike: Painting in the Third Dimension, Sweeney Art Gallery, University of California, Riverside (2008); Something from Nothing, Contemporary Art Center, New Orleans (2008); Soundwaves, Museum of Contemporary Art, San Diego (2007); California Biennial, Orange County Museum of Art, Newport Beach (2004); kurzdavordanach, Photographische Sammlung/SK Stiftung Kultur, Cologne, Germany (2004); and Black Belt, Studio Museum in Harlem (2003).